Relationship between Magnesium Concentration and Severity of Patients’s Traumatic Brain Injury

Muhammad Z. Arifin, Firman Priguna, Arwinder S. Gill


Neuronal damage in traumatic brain injury is caused by primary injury at the time of the event and also delayed processes following the injury. Alterations in ion homeostasis have been implicated for the occurrence of this progressive secondary injury cascade. Magnesium is one of the most important ions that affect many metabolism in the CNS. Magnesium (Mg2+) levels in the blood have been shown to be depressed for hours to days following head injury. The objective of this study is to define the relationship between levels of ionized magnesium concentration and severity of traumatic brain injury. Analysis of data was carried out through a retrospective review of medical records and based on a systematized database pertaining to patients with head injury treated in Neurosurgery ward Hasan Sadikin Hospital Bandung in March 2011– August 2011. A GCS score was assigned and blood sample was obtained within 24 h upon presentation. Patients were grouped into three categories: Group 1 (GCS 14-15), Group 2 (9-13) and Group 3(GCS<9), consisting of 18 patients each. There were 40 males and 14 females with average age of 32 years. Average levels of ionized Mg2+in Group 1 were 2.12 mg/dL, p=0.0, CI=0.27 (0.14–0.40 ), Group 2=1.84 mg/dL, p=0.0, CI=0.47 (0.34–0.60) and Group 3=1.65 mg/dL, p=0.0, CI=0.19 (0.06–0.32). The conclusion of this study is that decrease in the serum magnesium (Mg2+) concentration is considered to be related to the severity of the injury.


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