Profile Trigliserid Serum on Hypercholesterolemi Rats by Ethanol Extract of Lingzhi Mushroom (Ganoderma lucidum)

Eka Dewi Ayuningtyas, Arifah Sri Wahyuni


Introduction: Lingzhi mushroom (Ganoderma lucidum) is the herbal medicine that have antiinflammatory, hepatoprotective, hypoglycemic, hypotensive, and hypolipidemic activities. Lingzhi mushroom contain triterpenoid that reported has hypolypidemic activity by cholesterol syntesis inhibitor.

Objectives: Determine the triglyceride profile on hypercholesterolemi rats by ethanol extract of lingzhi mushroom.

Methods: There are 20 rats that were divided 4 groups. Group 1 was given standard diet. Group 2,3,4 were given high-fat diet then given standard diet and aquadest 2.5 ml/200mg body weight (for group 2), diet standar and ethanol extract of lingzhi mushroom 200, 400 mg/kg body weight (for group 3, 4).

Results: After treatment, levels triglycerides in all groups decrease. The decreasing triglyceride levels did not significantly between groups 3, 4 with group 2 and group 1 (p>0.05).

Conclusion: Administration ethanol extract of lingzhi mushroom did not affect on the level triglyceride in hipercholesterolemi rats.


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